She slammed her sibling's paparazzi ordeal as "far-fetched", seemingly questioning the statement from Prince Harry's team.
They said on Thursday: "The Duke and Duchess of Sussex and Ms Ragland were involved in a near-catastrophic car chase at the hands of a ring of highly aggressive paparazzi.
"This relentless pursuit, lasting over two hours, resulted in multiple near collisions involving other drivers on the road, pedestrians and two NYPD officers."
Samantha has since questioned where the Duke and Duchess got the term "near catastrophic when there was no impact".
"How is it near catastrophic," she asked on GB News. 'Because you're imagination says so?"
She added: "And I guess for some getting out of bed can be catastrophic because you never know what is going to happen by the end of the day.
"So it all just seems so dramatic and far fetched."
Samantha said that Meghan should not be acting "like the victim".
She later alleged that her sister had an "obsession" with Prince Harry's late mother, Princess Diana.
"Let's not forget the lifetime drama escaping the palace, when at the end of the drama she is depicted dying similarly to how Diana did," Samantha explained.
"Now if that's not a little bit eerie and that's not a little bit obsessed then please tell me what is."